Statistical physics, optics and cells

통계 물리학, 광학 및 세포

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통계 물리학, 광학 및 세포

저희 연구소에서는 광학, 연성물질물리학, 세포생물학의 교차지점에 있는 근원적인 문제들을 실험과 이론을 통해 연구하고있습니다. 수년간 저희는 분자유전학, 통계물리학, 이미징, 광학을 비롯하여 인식론등을 연구수단으로서 활용해왔습니다. 세포생물학에서는 세포의 내재적속성과 창발적속성을 대조한 문제를 제기합니다. 저희는 해당문제에대한 운용적정의를 제시하였으며 나아가 창발적속성으로부터 내재적속성을 실험적으로 해결하고자하는바입니다. 빛 그리고 생물・무생물을 망라하는 빛-물질 간의 다양한 상호작용을 향한 저희의 심취는 이미징, 응용광학, 발광, 광산란, 통계광학으로 연구를 이끌고 있습니다. 최근 저희가 발견한 임의적빛간섭계측법에 덕분에 이제 저희는 이론과 다양한 실험을 통한 통계광학의 신분야를 탐구할 수 있게 되었으며 이는 생명공학,연성 물질 물리학, 유전체분광학및광학센서기술에 응용되게됩니다.
Our laboratory investigates a few fundamental problems at the cross-roads of optics, soft-matter physics and cell biology, through experiments and theory. Over the years, we used a range of concepts and tools from molecular genetics, statistical physics, imaging, optics or epistemology. In cell biology, we raise the issue of intrinsic vs. emergent properties of cells, and we proposed an operational definition of this problem. We now wish to experimentally resolve intrinsic from emergent properties, using randomly activated genetic switches. Our fascination for light and its multiple interactions with living and non-living objects drives our research on imaging and applied optics, luminescence, light scattering and statistical optics. Following our recent discovery of random-light interferometry, we now explore this new field of statistical optics using theory and experiments, with applications to biology, soft-matter dynamics, dielectric spectroscopy, and optical sensor technologies. Cavity-amplified light scattering is one of the promising applications.

Major research field

cell biology and sociology, soft-matter and biological physics, statistical optics and interferometry

Desired field of research

Physics, Biology and teaching science better

Research Keywords and Topics

Biology and physical biology: Cell mechanics, cytoskeleton, cell adhesion, optical control of gene expression, sociology of the epithelial-to-mesenchymal transition.

Physics and biological physics: nonlinear optical imaging; thermal optics, nanoscale heat transfer and water metastability; ultraweak luminescence and the oxidative stress; diffusive wave spectroscopy and cavity-amplified light scattering, dynamics of protein activity.

Statistical optics: volume optical interferometry experiments theory; statistical theory of high symmetry light, stochastic dielectric spectroscopy, statistics of the dielectric tensor.

Research Publications
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ACS Nano 2022/ Cavity-Amplified Scattering Spectroscopy Reveals the Dynamics of Proteins and Nanoparticles in Quasi-transparent and Miniature Samples. Graciani G, King JT, and F Amblard. 16:16796-16805.
Communication Physics 2022/ 3D stochastic interferometer detects picometer deformations and minute dielectric fluctuations of optical volume. Graciani G, Filoche M and F Amblard. 5:239.
Scientific reports 2021/ Stochastic light concentration from 3D to 2D reveals ultraweak chemi- and bioluminescence. Khaoua I, Graciani G and F Amblard. 11:10050.
Nat communications 2019/ Super-resolution provided by the arbitrarily strong superlinearity of the blackbody radiation. Graciani G and F Amblard. 10:5761.
PNAS 2018/ How to better focus waves by considering symmetry and information loss. Lou K, Granick S and F Amblard. 115:6554.
Optics lett 2018/ Deep line-temporal focusing using intracavity control and incoherent pulse-shaping. Lou K, Wang B, Granick S and F Amblard. 43:4919.

Patents

1. "Multiphoton imaging installation." US Patent # 6879394 (2000).
2. "Method and apparatus for measuring optical power of a light beam produced in a microscope." US20100134791A1 - PCT/EP2007/009612 (2007).
3. "Methods and devices for detecting macroions in a liquid medium". WO2014006561A2- PCT/EP201214 (2012).
4. “Random Interferometer and Random Interferometric Analysis Method”. Korean patent KR102367812B1 (2019).

국가과학기술표준분류

  • NB. 물리학

국가기술지도분류

  • 정보-지식-지능화 사회 구현