TaejoonLab

기능유전체 연구실

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기능유전체 연구실

We studies the function of human genes involved in diseases, based on their deep homology in multiple organisms. By utilizing large-scale functional genomic data in multiple organisms, we computationally infer the role of uncharacterized genes (or novel function of already characterized genes) in phenotype that we are interested in. By integrating engineering perspectives, we also develop novel experimental platform to validate our predictions in model organisms.

Major research field

Functional genomics, Proteomics, Model organisms, Disease modeling

Desired field of research

Rare genetic disease modeling

Research Keywords and Topics

· Disease gene study for screening and diagnostics, integrating multi-omics data with images.
· Ciliopathy modeling in the mucociliary epithelium of Xenopus embryos
· Deep homology-based study for cross-species genotype-phenotype relationship

Research Publications
MORE

· Proc Natl Acad Sci USA, Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9, Kwon T, Ra JS, Lee S, Baek I-J, Khim KW, Lee EA, Song EK, Otarbayev D, Jung W, Park YH, Wie M, Bae J, Cheng H, Park JH, Kim N, Seo Y, Yun S, Kim HE, Moon HE, Paek SH, Park TJ, Park YU, Rhee H, Choi JH, Cho SW, Myung K (2022)
· Aging Cell, Adaptive cellular response of the substantia nigra dopaminergic neurons upon age-dependent iron accumulation, Kwon K, Cho H, Lee S, Cho EJ, Yu W, Kok CYL, Je HS, Kim JI, Cho HJ, Kwon T (2022)
· Cell Rep., Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER, Hwang H, Yun S, Arcanjo RB, Divyanshi, Chen S, Mei W, Nowak RA, Kwon T, Yang J (2022)

Patents

· MICROBE DETECTION METHOD USING FISH ANALYSIS, J KANG, T KWON, H KIM, S KIM, M LEE, H HYUN, HS KO (2020.12.)
· COMPOSITION FOR INDUCING DEATH OF CELLS HAVING MUTATED GENE, AND METHOD FOR INDUCING DEATH OF CELLS HAVING MODIFIED GENE BY USING COMPOSITION, K MYUNG, T KWON, I-J BAEK, JS Ra, Y SEO, S YUN (2019. 11.)

국가과학기술표준분류

  • LA. 생명과학
  • LA02. 유전학·유전공학
  • LA0205. 형질전환 생물모델

국가기술지도분류

  • 건강한 생명사회 지향
  • 021900. 생체정보분석/활용 기술

6T분류

  • BT 분야
  • 기초/기반기술
  • 020111. 유전체기반 기술