Bioorganic and Chembio Lab

생유기화학 및 화학생물학 연구실

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생유기화학 및 화학생물학 연구실

As a chemical biology research group, our goal is to understand complex biological systems at the molecular level using tools of synthetic chemistry. For this, we design and synthesize novel molecular tools, ranging from small molecules to peptides and modified proteins, in order to provide unique and innovative solutions to important biological problems. In this respect, our research program has three "elements" – synthetic chemistry, molecular design, and biological applications. In our group, they are synergist cally integrated for innovative chemical biology research. We are also expanding our research scope to bioenergy production and plastic degradation.

Major research field

Chemical Biology, Drug Discovery, Kinase, Phosphatase, Chemical Proteomics

Desired field of research

Novel antibiotics, Drug resistance, Anticancer, Bioenergy

Research Keywords and Topics

- Discovery and characterization of novel protein kinases and phosphatases
- Chemical proteomics
- Novel antibiotics against drug-resistant bacteria
- Biomimetic recycling of plastics

Research Publications
MORE

Bioorg. Chem. "A Simple Protein Histidine Kinase Activity Assay for High-throughput Inhibitor Screening" 2023, 130, 106232
J. Am. Chem. Soc "Ir and NHC Dual Chiral Synergetic Catalysis: Mechanism and Stereoselectivity in γ-Butyrolactone Formation" 2022, 144, 16171.
Chem. Commun. "Distinct Phosphorylation and Dephosphorylation Dynamics of Protein Arginine Kinases Revealed by Fluorescent Activity Probes" Jung, H.; Choi, Y.; Lee, D.; Seo, J. K.; Kee, J.-M.* 2019, 55, 7482-7485.
J. Am. Chem. Soc. "A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism" Oslund, R. C.; Kee, J.-M.; Anthony D. Couvillon, A. D.; Bhatia, V. N.; Perlman, D. H.; Muir, T. W.* (co-first authors) 2014, 136, 12899–12911 .
Nature Chemical Biology, “A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation” Kee, J.-M.; Oslund, R. C.; Perlman, D. H.; Muir, T. W.* 2013, 9, 416–421.

Patents

PCT/KR2021/015114 "COMPOSITION AND METHOD FOR MEASURING HISTIDINE KINASE ACTIVITY, AND METHOD FOR SCREENING HISTIDINE KINASE INHIBITORS BY USING THE SAME"; filed on Oct 26th, 2021.
U.S. Patent 10,351,581 “Phosphohistidine Mimetics and Antibodies to Same”; issued on July 16th, 2019.
U.S. Patent 9,765,154 “Phosphohistidine Analogs”; issued on September 19th, 2017.
U.S. Patent 8,536,378 “Prostratin and Structural or Functional Analogs Thereof”; issued on September 17, 2013

국가과학기술표준분류

  • NC. 화학
  • NC02. 유기화학
  • NC0207. 생유기화학

국가기술지도분류

  • 건강한 생명사회 지향
  • 020300. 선도물질도출기술

녹색기술분류

  • 에너지원기술
  • 재생에너지
  • 221. 바이오 에너지생산 요소기술 및 시스템 기술

6T분류

  • BT 분야
  • 기초/기반기술
  • 020114. 생명현상 및 기능연구