Bioorganic and Chembio Lab

생유기화학 및 화학생물학 연구실

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As a chemical biology research group, our goal is to un- derstand complex biological systems at the molecular level using tools of synthetic chemistry. For this, we design and synthesize novel molecular tools, ranging from small molecules to peptides and modified proteins, in order to provide unique and innovative solutions to important biological problems. In this respect, our research program has three "elements" – synthetic chemistry, molecular design, and biological applications. In our group, they are synergist cally integrated for innovative chemical biology research.

우리 연구실의 목표는 유기합성화학과 화학생물학(chemical biology)의 도구를 이용하여 복잡한 생물학적 시스템을 분자적 수준에서 이해하는 것입니다. 이를 위해, 저분자 물질, 펩타이드, 합성단백질에 이르는 다양한 새로운 분자 도구를 설계하고 합성하며, 이러한 도구들을 이용하여 생물학의 중요한 문제들에 대해 창 의적이고 혁신적인 해답을 제시하고, 궁극적으로 차세대 항암제, 항생제 개발의 기반을 마련하고자 합니다. 이러한 측면에서, 우리 연구실에서는 유기합성화학, 분자 설계, 그리고 생물학적 응용이라는 3가지의 요소가 결합된 융합 연구를 진행하고 있습니다.


생유기화학 및 화학생물학 연구실

관심분야

Chemical Biology, Drug Discovery, Kinase, Phosphatase, Chemical Proteomics 화학생물학, 신약개발, 인산화효소, 탈인산화효소, 화학단백체학

희망분야

Novel antibiotics, Drug resistance, Anticancer, Bioenergy, 차세대 항생제, 약물저항성, 항암제, 바이오에너지

Research Keywords and Topics

- Discovery and characterization of novel protein kinases and phosphatases
- Chemical proteomics
- Novel antibiotics against drug-resistant bacteria

Research Publications
MORE

Chem. Commun. "Distinct Phosphorylation and Dephosphorylation Dynamics of Protein Arginine Kinases Revealed by Fluorescent Activity Probes" Jung, H.; Choi, Y.; Lee, D.; Seo, J. K.; Kee, J.-M.* 2019, 55, 7482-7485.
J. Am. Chem. Soc. "A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism" Oslund, R. C.; Kee, J.-M.; Anthony D. Couvillon, A. D.; Bhatia, V. N.; Perlman, D. H.; Muir, T. W.* (co-first authors) 2014, 136, 12899–12911 .
Nature Chemical Biology, “A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation” Kee, J.-M.; Oslund, R. C.; Perlman, D. H.; Muir, T. W.* 2013, 9, 416–421.

Patents

U.S. Patent 10,351,581 “Phosphohistidine Mimetics and Antibodies to Same”; issued on July 16th, 2019.
U.S. Patent 9,765,154 “Phosphohistidine Analogs”; issued on September 19th, 2017.
U.S. Patent 8,536,378 “Prostratin and Structural or Functional Analogs Thereof”; issued on September 17, 2013