Viral Immunology Lab

바이러스 면역학 연구실

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We study how the host innate immune system detects viral infections and determines host fate through inflammatory cell death pathways. Utilizing genome-wide CRISPR knockout screening and innate immune sensor KO mouse libraries, we identify novel sensors and dissect pathways such as PANoptosis. By translating these insights, we aim to develop next-generation therapeutics targeting innate immune pathways.

Major research field

Innate Immunity, Virology, Infection Biology, Cell death Biology

Desired field of research

Antiviral Drug Discovery, Vaccine Development

Research Keywords and Topics

Virus, Innate immunity, Cell death, Inflammasome, Inflammation, PANoptosis

Research Publications

1. Herpes simplex virus1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense
Nature communications (IF: 17) (2026)
2. Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease.
Science Advances (IF: 12) (2026)
3. AIM2 drives inflammatory cell death and monkeypox pathogenesis
Cellular & Molecular Immunology (IF: 22) (2025)
4. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular & Molecular Immunology (IF: 22) (2023)
5. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Science Immunology (IF: 17) (2022)
6. AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
Nature (IF: 48) (2021)
7. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium
Science Immunology (IF: 17) (2019)

국가과학기술표준분류

  • LA. 생명과학
  • LA04. 면역학·생리학
  • LA0402. 선천성 면역