Viral Immunology Lab

바이러스 면역학 연구실

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Innate immunity is the first line of defense against infectious disease. The resulting inflammation is the first response to infection and injury. Pathogen sensing and signaling in innate immune and barrier cells drive inflammation to combat infection. Excessive or chronic inflammation can contribute to the development and many diseases including autoimmune disorders and cancer. Our laboratory seeks to gain fundamental insight into innate immune mechanisms to identify novel processes and new molecular targets. This will inform the development of therapeutic strategies.


Innate Immunity, Virology, Infection Biology, Cell death Biology


Antiviral Drug Discovery, Vaccine Development

Research Keywords and Topics

Virus, Innate immunity, Cell death, Inflammasome, Inflammation, PANoptosis

Research Publications

1. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
R. Karki*, S. Lee* et al., (*Equal contribution) Science Immunology (IF: 17.7), May 19 2022;eabo6294. (PMID: 35587515)
2. AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
S. Lee et al., Nature (IF: 49.96) Sept. 01, 2021 (PMID: 34471287)
3. Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
S. Lee et al., Trends in Immunology (IF: 16.68) 2020, Oct (PMID: 33153908)
4. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium
S. Lee et al., Science Immunology (IF: 17.7), 2019 Oct 25;4(40). pii: eaau4643 (PMID: 31653718)


  • LA. 생명과학
  • LA04. 면역학·생리학
  • LA0402. 선천성 면역