Viral Immunology Lab

바이러스 면역학 연구실

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Innate immunity is the first line of defense against infectious disease. The resulting inflammation is the first response to infection and injury. Pathogen sensing and signaling in innate immune and barrier cells drive inflammation to combat infection. Excessive or chronic inflammation can contribute to the development and many diseases including autoimmune disorders and cancer. Our laboratory seeks to gain fundamental insight into innate immune mechanisms to identify novel processes and new molecular targets. This will inform the development of therapeutic strategies.

Major research field

Innate Immunity, Virology, Infection Biology, Cell death Biology

Desired field of research

Antiviral Drug Discovery, Vaccine Development

Research Keywords and Topics

Virus, Innate immunity, Cell death, Inflammasome, Inflammation, PANoptosis

Research Publications

1. Inflammasome diversity: Exploring novel frontiers in the innate immune response
Trends in Immunology (IF: 21.09), 2024, March. 21. 2024
2. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular & Molecular Immunology (IF: 24.1) Nov. 27, 2023
3. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Science Immunology (IF: 30), May 19 2022
4. AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
Nature (IF: 69) Sept. 01, 2021
5. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium
Science Immunology (IF: 30), 2019 Oct 25


  • LA. 생명과학
  • LA04. 면역학·생리학
  • LA0402. 선천성 면역