Cancer/DNA damage Lab

암/유전자 손상 반응 실험실

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암/유전자 손상 반응 실험실

My lab focuses on studying the DNA damage response pathway and development/progression of chronic myeloid leukemia (CML).
DNA damage responses are important in maintaining genetic stability in eukaryotic cells. Because many tumor suppressor proteins including ATM, ATR, MDC1, RNF8, RNF168, RAP80, BRCA1, and BRCA2 are involved in the DNA damage pathway, the complete understanding of this pathway is important in preventing neoplastic transformation. So, our laboratory’s goal is to understand the inherent genetic stability and molecular mechanisms of tumorigenesis by studying DNA damage signaling pathways. CML study is the second project in my Lab. My Lab has focused on identifying genes that are resistant to the tyrosine kinase inhibitor of CML. In addition, we are studying the molecular mechanisms of the discovered genes and applying them to CML patients. The aim of this research project is to ultimately contribute to the treatment and diagnosis of chronic myelogenous leukemia.

Major research field

DNA damage, Cancer, CML

Desired field of research

Research Keywords and Topics

1. DNA 손상 연구
(1)Double strand break 손상 신호에 대한 연구 주제
1) 손상 신호 전달에서 RAP80와 BRCA1의 기능 분석
- DNA 손상 복구 (HR and NHEJ)
- Cell cycle checkpoint
2) DNA 손상에서의 후성 유전 조절 규명
- Histone modification
- Chromatin remodeling
(1) DNA Interstrand crosslinks (ICLs) repair 연구
1) ICL repair에서 TRAIP와 ZNF212의 기능 분석
- ICL repair 손상 복구 (FA and NEIL3 pathway)
- Cell cycle checkpoint

2. 백혈병 진행 연구
(1) CML 치료제 내성 및 병기 진행 환자 샘플 유전체 분석
- Microarray
- WGS, WES, Single cell analysis
(2) CML 치료제 내성 및 병기 진행 기전 분석
- Identification of binding proteins
- Functional analysis of identified proteins

Research Publications

1. Autophagy. GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.
Han SH, Korm S, Han YG, Choi SY, Kim SH, Chung HJ, Park K, Kim JY, Myung K, Lee JY, Kim H, Kim DW. 2019

2. Leukemia. Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia.
Han SH, Kim SH, Kim HJ, Lee Y, Choi SY, Park G, Kim DH, Lee A, Kim J, Choi JM, Kim Y, Myung K, Kim H, Kim DW. 2017

3. Nature communication. TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Lee NS, Chung HJ, Kim HJ, Lee SY, JJi J, Seo Y, Han SH, Choi M, Yun M, Lee SG, Myung K, Kim Y, Kang HC, Kim H. 2016

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0101. 신호전달