DNA Damage Response and Genetic Toxicology

유전체 손상 반응 및 독성물

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유전체 손상 반응 및 독성물

Our research focuses on understanding basic mechanisms of mutagenesis and on fail-safe mechanisms that ensure faithful genome maintenance and the elimination of compromised cells by programmed cell death. We mainly use C. elegans as an invertebrate model organism and employs advanced genetics, genomics, cell biology and next generation sequencing based approaches. Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus, many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. At the same time, we use mammalian cells to translate our insights gained from the invertebrate model. Our studies are relevant for understanding fundamental mechanisms leading to cancer formation and also aimed to better understand and more effectively use a range of agents commonly used for cancer therapy. We are engaged in multiple national and international collaborations.

Major research field

DNA repair, mutagenesis, next generation sequencing. C. elegans, genetics, DNA damage response

Desired field of research

Genome Stability

Research Keywords and Topics

We are interested in how cell deal with persistent DNA bridges just before cell divide.
We are interested in the mutagenic process of cancer chemotherapeutic agents.
We are interested in DNA repair mechanisms

Research Publications

bioRxiv / Systematic analysis of mutational spectra associated with DNA repair deficiency in C. elegans / B Meier, NV Volkova, Y Hong, S Bertolini, V González-Huici, T Petrova, S Boulton, PJ Campbell, M Gerstung, A Gartner / 2020-06
Nature Communications / Moritz Gerstung Mutational signatures are jointly shaped by DNA damage and repair / Nadezda V Volkova, Bettina Meier, Víctor González-Huici, Simone Bertolini, Santiago Gonzalez, Federico Abascal, Iñigo Martincorena, Peter J Campbell, Anton Gartner / 2020-11
Nature Communications / LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during cytokinesis / Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner / 2018-02


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  • LA02. 유전학·유전공학
  • LA0201. 분자유전학


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  • 021600. 유전자조작/전달기술


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  • 999. 녹색기술 관련과제 아님


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