Bioorganic and Chembio Lab

생유기화학 및 화학생물학 연구실

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생유기화학 및 화학생물학 연구실

우리 연구실의 목표는 유기합성화학과 화학생물학(chemical biology)의 도구를 이용하여 복잡한 생물학적 시스템을 분자적 수준에서 이해하는 것입니다. 이를 위해, 저분자 물질, 펩타이드, 합성단백질에 이르는 다양한 새로운 분자 도구를 설계하고 합성하며, 이러한 도구들과 화학단백체학, 단백질 생화학, 의약화학의 방법론을 융합적으로 이용하여, 궁극적으로 차세대 항암제, 항생제 개발의 기반을 마련하고자 합니다. 또한 이를 바이오에너지 생산 및 생체모방 플라스틱 분해 등으로 확장 응용하는 연구 또한 진행중입니다.

As a chemical biology research group, our goal is to understand complex biological systems at the molecular level using tools of synthetic chemistry. For this, we design and synthesize novel molecular tools, ranging from small molecules to peptides and modified proteins, and utilize them in proteomics, protein biochemistry, and drug discovery. We are also expanding our research scope to bioenergy production and plastic degradation.

Major research field

화학생물학, 신약개발, 인산화효소, 탈인산화효소, 화학단백체학 / Chemical Biology, Drug Discovery, Kinase, Phosphatase, Chemical Proteomics

Desired field of research

차세대 항생제, 약물저항성, 항암제, 바이오에너지, 플라스틱 분해 / Novel antibiotics, Drug resistance, Anticancer, Bioenergy, Plastic degradation

Research Keywords and Topics

- 단백질 인산화/탈인산화효소 기능 연구 / Discovery and characterization of novel protein kinases and phosphatases
- 화학단백체학 / Chemical proteomics
- 신약개발 / Novel antibiotics against drug-resistant bacteria
- 생체모방 플라스틱 분해 / Biomimetic recycling of plastics

Research Publications
MORE

Nat. Commun. "Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes" 2025, 16, 7757
Chem. Sci. "Chemoproteomic identification of phosphohistidine acceptors: posttranslational activity regulation of a key glycolytic enzyme" 2025, 16, 8014.
Bioorg. Chem. "A Simple Protein Histidine Kinase Activity Assay for High-throughput Inhibitor Screening" 2023, 130, 106232
Chem. Commun. "Distinct Phosphorylation and Dephosphorylation Dynamics of Protein Arginine Kinases Revealed by Fluorescent Activity Probes" 2019, 55, 7482-7485.
J. Am. Chem. Soc. "A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism" 2014, 136, 12899–12911 .
Nature Chem. Biol. “A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation” 2013, 9, 416–421.

Patents

PCT/KR2021/015114 "COMPOSITION AND METHOD FOR MEASURING HISTIDINE KINASE ACTIVITY, AND METHOD FOR SCREENING HISTIDINE KINASE INHIBITORS BY USING THE SAME"; filed on Oct 26th, 2021.
U.S. Patent 10,351,581 “Phosphohistidine Mimetics and Antibodies to Same”; issued on July 16th, 2019.
U.S. Patent 9,765,154 “Phosphohistidine Analogs”; issued on September 19th, 2017.
U.S. Patent 8,536,378 “Prostratin and Structural or Functional Analogs Thereof”; issued on September 17, 2013

국가과학기술표준분류

  • NC. 화학
  • NC02. 유기화학
  • NC0207. 생유기화학

국가기술지도분류

  • 건강한 생명사회 지향
  • 020300. 선도물질도출기술

녹색기술분류

  • 에너지원기술
  • 재생에너지
  • 221. 바이오 에너지생산 요소기술 및 시스템 기술

6T분류

  • BT 분야
  • 기초/기반기술
  • 020114. 생명현상 및 기능연구