Our mission is to utilize and integrate data-based and knowledge-based models to define and solve various meaningful problems in medicine and biology. We deal with various types of data, including time series. To achieve this, we utilize diverse methodologies, including statistics, control, optimization theory, as well as machine learning and artificial intelligence. From the science of discovering knowledge to the engineering of proposing new applications, we aim to address not only the unmet demands in clinical medicine and biology but also to identify and solve undiscovered needs. We explore in the areas of methodology research and practical field applications, ranging from prediction and inference to decision-making and implementation in the biomedical sciences and clinical fields.