비만 연관 당뇨 및 암 질환의 분자 기전을 밝히고 치료제 개발을 위한 연구를 진행하고 있습니다.
· 세포외 기질단백질에 의한 지방조직 리모델링 연구
· 지방조직 분비체 기반 대사성 질환 치료제 개발 연구
· 종양미세환경에서 지방세포와 암세포간의 상호신호 전달계 연구
· 대사스트레스에 의한 암세포 대응기전 연구
Our research group is mainly focusing on the adipocyte biology at the level of metabolism and cancer. Through underlying the molecular mechanisms of obesity-related metabolic diseases, we aim to develop novel therapeutics for the metabolism and cancers. Main research topics are listed in below;
· Adipose tissue remodeling via modulation of extracellular matrix proteins
· Development of adipokine-based therapeutics for obesity-related metabolic diseases
· Underlying the signaling networks between stromal adipocytes and cancer cells within the tumor microenvironment
· Underlying the molecular mechanisms of metabolic stress-induced alteration of cancer cell behaviors