High Pressure X-ray Science Laboratory

고압력 X선 물리연구실

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고압력 X선 물리연구실

Our lab studies biological and soft matter systems using high-pressure and X-ray techniques. A high-pressure cryocooling method was developed for crystal cryoprotection in macromolecular crystallography. In addition, the method was successfully applied to stabilize ligand-protein interactions, to study the pressure effect on the structure, and to entrap intermediate enzymatic states. Using the high-pressure method, we will study the phase behaviors of glassy water, water-protein interactions, and protein functions and dynamics at cryogenic temperatures.

Major research field

X-ray Science, Biophysical Science, Biomedical Science

Desired field of research

Protein Structures and Functions, High-Pressure Cryocooling Protein Crystallography

Research Keywords and Topics

X-ray Science, Biophysical Science, Biomedical Science:
X-ray Technique Development, Protein Structures and Functions, X-ray Imaging of Biological Assemblies

Research Publications
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IUCrJ / Structural insights into the effect of active site mutation on carbonic anhydrase catalytic mechanism / Kim, Jin Kyun; Lee, Cheol; Lim, Seon Woo; Andring, Jacob T.; Adhikari, Aniruddha; McKenna, Robert; Kim, Chae Un / 2020-11
Nature Communications / Elucidating the role of metal ions in carbonic anhydrase catalysis / Kim, Jin Kyun; Lee, Cheol; Lim, Seon Woo; Adhikari, Aniruddha; Andring, Jacob T.; McKenna, Robert; Ghim, Cheol-Min; Kim, Chae Un / 2020-09
IUCrJ / Active-site solvent replenishment observed during human carbonic anhydrase II catalysis / Kim, Jin Kyun; Lomelino, Carrie L.; Avvaru, Balendu Sankara; Mahon, Brian P.; McKenna, Robert; Park, Sang Youn; Kim, Chae Un / 2018-01
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / Glass-to-cryogenic-liquid transitions in aqueous solutions suggested by crack healing / Kim, Chae Un; Tate, Mark W.; Gruner, Sol M. / 2015-09

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