Laboratory of Molecular Immunology

분자면역학 연구실

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We study the immunologic aspects of a very broad range of human diseases, encompassing investigations in the fields of autoimmune diseases, inflammatory diseases, and hematopoiesis such as rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis and leukemia. We are interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, monocytes and fibroblasts. We are currently studying how cytokines such as IFNs, TNF and IL1 reprogram macrophage responses to the environment by altering transcription factor networks, chromatin states, cell metabolism, and the epigenomic landscape of enhancers. Such reprogramming results in macrophages that are hyper-responsive (primed) or desensitized (tolerized) to inflammatory challenges. To understand of underlying mechanisms, we integrate basic science investigation of signaling and epigenetic mechanisms with translational research using disease models and analysis of human disease samples with genome wide approaches such as single cell RNA-seq, ChIP-seq, and ATAC-seq. We are incorporating a precision medicine approach to identify disease mechanisms and the best therapies for individual patients. Our long-term research goals are to identify signaling and epigenetic mechanisms that can be targeted by new therapies for inflammatory diseases, including biological approaches to enhancing clinical outcomes.

Major research field

Cytokine Imprints, Plasticity in Macrophages, Innate Immune Memory, Chronic Inflammatory Diseases, Leukemia

Desired field of research

Bioinfomatics, NGS-based Approach

Research Keywords and Topics

Cytokine Imprints and Plasticity in Macrophages
Autoimmune Diseases and Leukemia
Bioinformatics and NGS

Research Publications

CIRCULATION / Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis / Jeon, Sejin; Kim, Tae Kyeong; Jeong, Se-Jin; Jung, In-Hyuk; Kim, Nayoung; Lee, Mi-Ni; Sonn, Seong-Keun; Seo, Seungwoon; Jin, Sang-Hak; Kim, Kyu-Won; Cybulsky, Myron, I; Shim, Hyunbo; Roh, Tae-Young; Park, Woong-Yang; Lee, Hae-Ock; Choi, Jae-Hoon; Park, Sung Ho; Oh, Goo Taeg / 2020-11
SCIENCE IMMUNOLOGY / Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 / Lee, Jeong Seok; Park, Seongwan; Jeong, Hye Won; Ahn, Jin Young; Choi, Seong Jin; Lee, Hoyoung; Choi, Baekgyu; Nam, Su Kyung; Sa, Moa; Kwon, Ji-Soo; Jeong, Su Jin; Lee, Heung Kyu; Park, Sung Ho; Park, Su-Hyung; Choi, Jun Yong; Kim, Sung-Han; Jung, Inkyung; Shin, Eui-Cheol / 2020-07
SCIENCE IMMUNOLOGY / VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancer

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