Molecular Biomedicine Lab

분자생의학 연구실

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분자생의학 연구실

Molecular Biomedicine Lab (MBL) is a global stem cell research group that has a network with Max Planck Institute, the world-leading research institute. MBL aims to develop novel stem cell technologies to treat incurable disease. Direct conversion is a technology that can generate target cells from skin cells by bypassing the pluripotent stage thereby solving the tumorigenic risk of pluripotent stem cell. MBL focuses on developing stem cell treatments that repair damaged tissues or damaged organs using patient-specific stem cell s generated by direct conversion and organoid technology.

Major research field

Reprogramming, Direct conversion, Spinal cord injury, Neurodegenerative disease, Organoid/assembloid

Desired field of research

Patient-specific stem cells, Organoid/assembloid, First-in-class drug, Drug development

Research Keywords and Topics

Our research is based on an understanding of the mechanism of iPS reprogramming, direct conversion and the generation of patient-specific stem cells for future cell therapy. The aim is to develop innovative cell therapy technologies for degenerative and incurable diseases. In addition, iPS cells and directly converted cells can be used for innovative cell-based platform to drug screening and toxicity tests. Therefore, the therapeutic potential of iPS cell and directly converted cells are very promising.

Research Publications
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• ELIFE, Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord model, LEE, H, Lee, HY, Lee, BE, Gerovska, D, Park SY, Zaehres, H, Araúzo-Bravo MJ, Kim, JI, Ha, Y, Schöler, HR, Kim, JB (2020, 06)
• CELL, Oct4-induced pluripotency in adult neural stem cells, Kim, JB, Sebastiano, V, Wu, G, Araúzo-Bravo, MJ, Sasse, P, Gentile, L, Ko, K, Ruau, D, Ehrich, M, van den Boom, D, Meyer, J, Hübner, K, Bernemann, C, Ortmeier, C, Zenke, Fleischmann, BK, Zaehres, H, Schöler, HR, (2009.02)
• NATURE, Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors, Kim JB, Zaehres, H, Wu, GM., Gentile, L, Ko, K, Sebastiano, V, Araúzo-Bravo, MJ, Rauu, D, Han, DW, Zenke, M, Schöler, HR, (2008, 07)

Patents

• Hydrogel Patch, Jeong Beom Kim and Donggyu Nam. 12/10/2019
• 신경 발화 패턴을 이용한 촉감의 모델링 방법, 촉감 모델 및 신경 발화 패턴을 이용한 촉감의 생성방법, 김성필, 박지성, 정승준, 장동표, 2018.09
• Composition for inducing direct conversion of somatic cell into oligodendrocyte progenitor cells and use the same, Jeong Beom Kim. 10/26/2017
• 영상컨텐츠의 몰입도 측정 방법 및 장치, 김성필, 강다윤, 조양석, 박완주, 2017.03

국가과학기술표준분류

  • LA. 생명과학
  • LA03. 발생·신경생물학
  • LA0306. 줄기세포생물학

국가기술지도분류

  • 건강한 생명사회 지향
  • 021500. 줄기세포 배양기술

6T분류

  • BT 분야
  • 보건의료 관련응용
  • 020213. 생체조직 재생기술