Cancer Epigenetics Laboratory


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How do alterations in epigenetic landscape disturb the barrier between normal and malignant states to cause cancers? How can we translate these cancer-related aberrations into more efficient cancer therapy? These are two overarching questions that our research is currently addressing. The intricate interplay between genetic and epigenetic pathways plays key roles in regulating normal and malignant cellular development.

Major research field

Cancer, solid cancers, hematologic malignancies, epigenetics, obesity, diabetes, metabolic disease, therapy

Desired field of research

Research Keywords and Topics

- 암 발생 원리 규명 (Dysregulation of key genetic and epigenetic players that leads to the onset and progression of cancers)
* 혈액암 및 고형암 발달 기전
* 생체내 대사, 염증 및 면역반응
* 유전자 발현 및 세포 분화의 후생유전학적 조절 기전
- 종양특이적 후생유전학적 변이를 표적으로 하는 신개념 항암 치료제

Research Publications

Nature / Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 / Ko et al. / 2010-12
Nature Communications / Acute loss of TET function results in aggressive myeloid cancer in mice / An et al. / 2015-11
Nature / Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein / Ko et al / 2013-05
Adv. Health. Mater. / Rapid and label-free detection of 5-hydroxymethylcytosine in genomic DNA using an Au/ZnO nanorods hybrid nanostructure-based electrochemical sensor/ Bhat et al./ 2021-11
PNAS / Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression / Byun et al. / 2022-6
PNAS / Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch / Hiroshi et al. /2023-1


TET 발현 또는 활성 저해에 의한 비만 및 대사질환 억제/고명곤, 변성준/2021


  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0105. 유전자 발현조절


  • 건강한 생명사회 지향
  • 021900. 생체정보분석/활용 기술


  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님


  • BT 분야
  • 기초/기반기술
  • 020114. 생명현상 및 기능연구