Molecular Metabolism Laboratory

분자대사학연구실

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분자대사학연구실

비만 연관 당뇨 및 암 질환의 분자 기전을 밝히고 치료제 개발을 위한 연구를 진행하고 있습니다.
· 세포외 기질단백질에 의한 지방조직 리모델링 연구
· 지방조직 분비체 기반 대사성 질환 치료제 개발 연구
· 종양미세환경에서 지방세포와 암세포간의 상호신호 전달계 연구
· 대사스트레스에 의한 암세포 대응기전 연구
Our research group is mainly focusing on the adipocyte biology at the level of metabolism and cancer. Through underlying the molecular mechanisms of obesity-related metabolic diseases, we aim to develop novel therapeutics for the metabolism and cancers. Main research topics are listed in below;
· Adipose tissue remodeling via modulation of extracellular matrix proteins
· Development of adipokine-based therapeutics for obesity-related metabolic diseases
· Underlying the signaling networks between stromal adipocytes and cancer cells within the tumor microenvironment
· Underlying the molecular mechanisms of metabolic stress-induced alteration of cancer cell behaviors

Major research field

Adipocyte, Obesity, Diabetes, Cancers, Therapeutics

Desired field of research

ECM and fibrotic diseases

Research Keywords and Topics

· Obesity-related metabolic diseases and cancers
· Adipose tissue remodeling
· Extracellular matrix protein (ECM) and fibrosis

Research Publications
MORE

· Oh J, Park C, Kim S, Kim M, Kim C-S, Jo W, Park S, Yi G-S, and Park J*. High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity. Metabolism-Clinical and Experimental (145) 155629 (IF: 13. 934) 2023.08
· Lee C, Kim M, Park C, Jo W, Seo JK, Kim S, Oh J, Kim C-S, Ryu HS, Lee K-H and Park J*. Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia. Nature Communications 14(1) 439 (IF: 17. 694) 2023.02
· Jo W, Kim M, Oh J, Kim C-S, Park C, Yoon S, Lee C, Kim S, Nam D, Park J*. MicroRNA-29 ameliorates fibro-inflammation and insulin resistance in HIF1α-deficient obese adipose tissue by inhibiting endotrophin generation. Diabetes (IF: 9.461) 2022.08. 71(8)1746-1762

Patents

· [국내] 엔도트로핀 절단 효소의 저해제를 포함하는 엔도트로핀 활성 저해용 조성물 및 이의 용도. 박지영, 김민, 이상민, 조우빈. 2020.02.03 (대한민국)
· [국외] Endotrophin neutralization and use thereof. Philipp.E. Scherer, Jiyoung Park, Zhiqiang An. 2017.03.28 (USA Patent)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0103. 세포분화/사멸

국가기술지도분류

  • 건강한 생명사회 지향
  • 021100. 생체신호처리기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 보건의료 관련응용
  • 020212. 난치성 질환 치료기술