CaSE / Cell and Signaling Engineering Lab

세포신호공학 연구실 (케이스)

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1. 다양한 세포내 칼슘 및 세포내 신호에 의한 다양한 세포기전을 이해함으로 질환기전 및 치료법 탐색
2. 역분화줄기세포 (iPSC)기반 브레인 세포 Organoid 및 Assembloids 기법을 기반하여 뇌발생 및 질환들(AD, PK, HD)의 기전 및 치료법 탐색

------- 6W1H -------
칼슘채널 기능 이해
세포신호 (칼슘 및 cAMP 신호기전) 이해
브레인 세포_신경세포의 발생 및 분화에 대한 기전 이해
다양한 세포(근육, 지방, 혈액세포, 암세포,,바이러스 감염세포, 등)내 칼슘채널의 특이적 기능 연구
이를 위한 최근 분자, 세포생물학 실험기법을 적용__현미경학(칼슘이미징), 전기생리학, 줄기세포, 분자생물학, 세포생물학 기법을 onsite 적용하는 곳

무엇보다도,
재미있고 발전적, 도움을 주는 연구를 하기 위하여, 좋은 실험실 및 과학자가 되기 위하여, 어떻게 함께 성장하는 가를 함께 고민하는 곳입니다.

The goal of our research is to understand how Ca2+ Channels and cellular signaling work in cancer cells and iPSC-derived differentiated RBC, Neurons, etc.
Numerous physiological processes, such as neuronal differentiation, cell proliferation, apoptosis, gene transcription, are regulated by Ca2+ Channels and diverse cell signaling.
Consequently, Ca2+ channels and Cellular signaling (Ca2+, cAMP) are important for many pathological processes and diseases, including autism, AD, PK, HD, immune deficiency syndrome, and cancers
To do this, we adopt the decent technologies, including CRISPR, iPSC, RBC, Brain Organoids and all possible molecular, cellular Biology and its related tecnologies.

Another goal is to provide effective solutions designed to boost your ability, to ensure you achieve your dreams of success, and to help you be a nice lab citizen.​

Major research field

역분화줄기세포, 오가노이드, 어셈블로이드, 칼슘채널, 세포내 신호, 세포분화 (신경, 근육, 지방, 혈액), 바이러스감염세포면역

Desired field of research

Cell therapy (LNP, ASO, etc), Transplantation, Translational Medicine

Research Keywords and Topics

· Calcium channels (STIM-Orai, VGCC)
· Cellular Signalings (Ca2+, cAMP)
· Cellular Differentiation (stem cell derived Brain Cells, Red Blood Cell, etc)
· Molecular and Cellular Engineering (iPSC, CRISPR, Display and Screeing)
· Translational medicine

Research Publications
MORE

· Advanced Science, Orai1 is an entotic Ca2+ channel for non-apoptotic cell death, entosis in cancer development, Lee AR and Park CY. (2023)
· Cell Reports, Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation. Lee SK, Kweon YC, LEE AR, Lee YY, and Park CY. (2022)
· PNAS, Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans. Kim KM, Wijerathne T, Hur JH, Kang UJ, Kim IH, Kweon YC, Lee AR, Jeong SJ, Lee SK, Lee YY, Sim BW, Lee JH, Baig C, Kim SU, Chang KT, Lee KP, Park CY (2018)

Patents

· CALCIUM SIGNALING MODULATORS INVOLVING STIM AND ORAI PROTEINS
(61/155,761) (International Publication Number WO 2010/099401A1)
· Organic compounds that inhibit or activate store operated calcium channels
(61/459,322) (International Patent Application No. PCT/US2011/064234)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0103. 세포분화/사멸

국가기술지도분류

  • 건강한 생명사회 지향
  • 021500. 줄기세포 배양기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 보건의료 관련응용
  • 020211. 바이오신약 개발기술