Molecular Oncology Laboratory

분자종양학 연구실

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분자종양학 연구실

암에서 발견되는 다양한 유전적 변이의 기능적 영향을 이해하고 이를 바탕으로 암세포 선택적 사멸 유도 전략을 제시하고자 합니다.
Our lab’s research goal is to promote our understanding of cancer with the aim of developing novel therapeutics that can be used as preventive and/or curative therapy. To this end, we are focusing on
understanding the functional impact of genetic alterations in cancer and suggesting an attractive strategy for safely treating cancer.
Our current research interests are:
• Understanding the molecular mechanisms of cancer development
• Identification of signaling pathways and molecular targets involved in cancers
• Study on the therapeutic strategies to selectively kill cancer cells

Major research field

Cancer Biology, Cell Biology_Organelle stress, Molecular Biology_RNA Splicing

Desired field of research

Cell Death Mechanisms, Anticancer therapeutic strategies

Research Keywords and Topics

• 암 발생의 분자 기전 이해
Understanding the molecular mechanisms of cancer development

• 암과 관련된 신호전달경로 및 분자 표적 규명
Identification of signaling pathways and molecular targets involved in cancers

• 암세포 선택적 사멸 유도 전략 연구
Study on the therapeutic strategies to selectively kill cancer cells

Research Publications
MORE

• Nano Today, CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse models. Jun H, Yeo M, Jeon JP, Eom S, Kim HJ, Kim Y, Jang E, Park SH*, Kim E*, Kang S* (202412)
• Cell Death & Disease, Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis. Lee DM, Kim IY, Lee HJ, Seo MJ, Cho, M-Y, Lee HI, Yoon G, Ji, J-H, Park SS, Jeong, S-Y, Choi EK, Choi YH, Yun C-O, Yeo M, Kim E*, Choi KS* (202401)
• Biochemical Pharmacology, Quercetin and Chloroquine Synergistically Kill Glioma Cells by Inducing Organelle Stress and Disrupting Ca2+ Homeostasis. Jan E, Kim IY, Kim H, Lee DM, Seo DY, Lee JA, Choi KS, Kim E*. (202008)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0199. 달리 분류되지 않는 분자세포 생물학

국가기술지도분류

  • 건강한 생명사회 지향
  • 020900. 안전성 및 약효분석?평가기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 기초/기반기술
  • 020114. 생명현상 및 기능연구