Calcium Dynamics Lab

칼슘다이나믹스

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세포내 칼슘신호가 세포에서 얼마나 중요한 일을, 어떻게 한는가를 연구하고자 합니다.
왜 신경세포, 근육세포, 지방세포, 혈액세포, 암세포,,바이러스 감염세포 등등,, 세포 특이적 기능을 나타내는가?
또한 최근 실험기법을 빠르게 적용, 최신 연구동향을 이끌것인가에 대한 고민을 함께 하는 곳

최근 코로나바이러스와 같은 바이러스 대응 세포내 칼슘신호전달 기작에 대한 연구를 시작하였습니다.

무엇보다도,
지속적이며 재미있는 연구를 하기 위하여, 좋은 실험실 및 과학자가 되기 위해서, 어떻게 성장하는 가를 함께 고민하는 곳입니다.
The goal of our research is to understand how calcium signaling is important and diverse. Numerous vital physiological processes such as cell division, proliferation, apoptosis, gene transcription, and immune cell activation are regulated by calcium channels. Consequently, calcium channels are important for many pathological processes and diseases including autism, immune deficiency syndrome, and cardiovascular diseases. We are interested in the dynamic calcium signaling events mediated by voltage-gated calcium channels (VGCCs) and store-operated calcium channels (SOCs).

One more thing!
Recently, we know and have interested in the role of calcium signaling in (coronavirus) viral immunity.

Another goal is to provide effective solutions designed to boost your ability, to ensure you achieve your dreams of success, and to help you be a nice lab citizen.​

Major research field

칼슘채널, 칼슘신호, 세포분화 (근육, 지방, 혈액), 면역반응 (세포성 및 바이러스감염) / Calcium channel mediated signaling, Cellular differentiation, Coronavirus, Innate immune.

Desired field of research

Research Keywords and Topics

· Calcium channel signaling
· Immune system activation
· Cell signaling
· Host cell responses to viral infection (Coronavirus infection)
· Translational medicine

Research Publications
MORE

· Proc. Natl Acad Sci U S A Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans. Kim KM, Wijerathne T, Hur JH, Kang UJ, Kim IH, Kweon YC, Lee AR, Jeong SJ, Lee SK, Lee YY, Sim BW, Lee JH, Baig C, Kim SU, Chang KT, Lee KP, Park CY (2018)
· Science. The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels. Science. (2010)
· Cell, STIM1 Clusters and Activates CRAC channels via Direct Binding of a Cytosolic Domain to Orai1. Park CY, Hoover PJ., Mullins F, P. Bachhawat, Covington ED., Raunser S., Walz T., Garcia KC., Dolmetsch RE, and Lewis RS, (2009)

Patents

· CALCIUM SIGNALING MODULATORS INVOLVING STIM AND ORAI PROTEINS
(61/155,761) (International Publication Number WO 2010/099401A1)
· Organic compounds that inhibit or activate store operated calcium channels
(61/459,322) (International Patent Application No. PCT/US2011/064234)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0101. 신호전달

국가기술지도분류

  • 건강한 생명사회 지향
  • 021100. 생체신호처리기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 보건의료 관련응용
  • 020211. 바이오신약 개발기술