Faculty Research Profile
Ja Hyoung Ryu
학력
2006: Ph. D. Yonsei University, Chemistry
2002: M. S. Yonsei University, Chemistry
2000: B. S. Yonsei University, Chemistry
주요 경력
2022-present: Professor, UNIST
2019-2022: Head of Department of Chemistry, UNIST
2016-2022: Associate Professor, UNIST
2012-2016: Assistant Professor, UNIST
2015-2021: Associate Editor, RSC Adv.
2011-2012: Assistant Research Professor, Seoul National University, Chemistry
2007-2011: Postdoctoral Fellow, University of Massachusetts, Amherst, Chemistry/Polymer chemistry
2006-2007: Postdoctoral Fellow, Yonsei University, Chemistry
수상/학회/외부활동
TCI Academic Award, Korean Chemical Society, Polymer chemistry, 2025
Sehi Jang Excellent Researcher Award, Organic Chemistry Division of the Korean Chemical Society, 2023
Osstem Implant Mid-Career Researcher Award, The Korean Society of Biomaterials, 2023
Mid-Career Researcher Academy Award, The Polymer Society of Korea, 2023
Rising-Star Distinguished Professor, UNIST, 2019
초분자나노재료연구실
Supramolecular NanoMaterials Lab
본 연구실에서는 초분자 화학의 접근법을 통한 새로운 질병 치료법(초분자 치료)에 대한 연구를 진행하고 있다. 유기합성을 통해 자극에 반응하는 새로운 유기분자/고분자를 개발하고, 이를 이용한 항암/노화 표적 약물전달, 초분자 자기조립 및 세포내 기능을 연구 하고 있다. 잘 조립된 나노 구조와 생체-나노물질의 개발을 통하여 세포 역활을 통제하거나 뛰어난 유-무기 하이브리드 물질을 이용하여 화학 생명 기술을 발전시키는것을 목표로 하고 있다.
The research theme of the Ryu research group is the development of new disease therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the conventional-drug-free approach for a new anti-cancer/anti-ageing therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer/senescent cells. In addition, the Ryu group have developed a facile synthetic method for highly stable, polymer/protein-modified hollow nanoparticles using a non-covalent approach to enhance in vivo efficacy and target ability to caner and senescent cells.
The research theme of the Ryu research group is the development of new disease therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the conventional-drug-free approach for a new anti-cancer/anti-ageing therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer/senescent cells. In addition, the Ryu group have developed a facile synthetic method for highly stable, polymer/protein-modified hollow nanoparticles using a non-covalent approach to enhance in vivo efficacy and target ability to caner and senescent cells.
연구분야
초분자 치료제 (Supramolecular Therapy), 나노의약 (Nanomedicine), 노화 제어
연구주제
Research Keywords :
초분자 치료, 세포내자기 조립, 항암치료, 항노화 치료(Supramolecular Therapeutics, Intracellular Self Assembly, Anti-Cancer, Anti-Ageing)
Research Interests/Topics :
항암 및 항노화 치료를 위한 나노메디신 개발(Nanomedicine for anti-cancer/anti-ageing therapy)
미토콘드리아 표적지향 약물개발(Mitochondria Targeting Drug)
세포내 초분자조립 연구(Intracellular Supramolecular Assembly)
리튬이온전지를 위한 다기능성 폴리머 개발(Multifunctional Polymers for Lithium Ion Batteries)
Research Keywords :
Supramolecular Therapeutics, Intracellular Self Assembly, Anti-Cancer, Anti-Ageing
Research Interests/Topics :
Nanomedicine for anti-cancer/anti-ageing therapy
Mitochondria Targeting Drug
Intracellular Supramolecular Assembly
Multifunctional Polymers for Lithium Ion Batteries
국가연구개발사업 기술 분류체계
국가과학기술표준분류
NC. 화학 > NC05. 고분자화학 > NC0504. 생체 의료용 고분자
논문
S. Kim, J.-B. Chae, D. Kim, C.-W. Park, Y. Sim, J. Kim, H. Lee, G. Park, J. Lee, S. Hong, B. Jana, C. Kim, H. Chung,* J.-H. Ryu* "Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells" J. Am. Chem. Soc. 2023, 145, 21991
B. Jana, S. Jin E. M. Go, Y. Cho, D. Kim, S. Kim, S. K. Kwak,* J.-H. Ryu* "Intra-Lysosomal Peptides Assembly for the High Selectivity Index against Cancer", J. Am. Soc. Chem. 2023, 145, 18414.
Y. Jeong,* L. Palanikumar, H. Choi, E. Shin, E. M. Go, C. Keum, S. Jin, D. Kim, M. Kim, H. Kim, K. H. Lee, B. Jana, M.-H. Park, S. K. Kwak,* C. Kim,* J.-H. Ryu** "Supramolecular nanomachine via molecular folding and unfolding" J. Am. Chem. Soc. 2022, 14, 5503
특허
Conjugate Including Peptide Molecule Capable of Self-Assembly in Cell Organelle and Pharmaceutical Composition for Preventing or Treating Cancer Including Conjugate” US Patent Application Number 15/813,646
Targeted Drug Delivery Platform Using Protein Corona Shield Nanoparticle and a Method for Producing the Same” Korean Patent Application Number 10-2017-0159936