Single Molecule Biophysics Group

단분자 생물물리학 연구실

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단분자 생물물리학 연구실

We look at “Life”, molecule by molecule. Single molecule approaches to biology and biophysics reveal unforeseen details about the building blocks of biology. From these, we can understand the role of fluctuations and the interplay of molecules, to open new insights into the functioning of the biomolecules. These insights can provide novel strategies toward biomedical problems as well as answers to scientific questions. We develop and combine cutting-edge single molecule and single cell techniques to solve important problems in biological science, including the organization and dynamics of chromosomes, biomolecular recognition/assembly, molecular machinery working on nucleic acids, and intrinsically disordered proteins. Our study requires cross-disciplinary efforts from biologists, physicists, chemists, and engineering scientists and we pursue collaborations with groups from diverse scientific disciplines. One of our major interests is to uncover the molecular level principles that govern the spatiotemporal organization of chromatin and its epigenetic control for regulating DNA repair and gene expression, eventually determining the fate of the cell.

관심분야

Single Molecule Dynamics, Molecular Motors, Genome Imaging, Chromatin Dynamics, Super-Resolution Microscopy, Single Molecule Mechanobiology

희망분야

Research Keywords and Topics

Research Keywords
Single Molecule Dynamics, Molecular Motors, Genome Imaging, Chromatin Dynamics, Super-Resolution Microscopy, Single Molecule Mechanobiology

Research Interests
Single molecule study of DNA replication and repair processes
Transcription initiation dynamics
Super-resolved imaging of genome dynamics
Visualization of 4D (spatiotemporal) organization of chromatin
Imaging-based identification and characterization of microbial species

Research Publications
MORE

The Dynamic Landscape of Transcription Initiation in Yeast Mitochondria, Nature Communications (2020)
Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes, Nature Communications (2019)
Evolution of Protein-Coupled RNA Dynamics during Hierarchical Assembly of Ribosomal Complexes, Nature Communications (2017)
Direct Evidence for Sequence-Dependent Attraction between Double-Stranded DNA Controlled by Methylation, Nature Communications (2016)
Protein-Guided RNA Dynamics during Early Ribosome Assembly, Nature (2014)
A Rule of Seven in Watson-Crick Base Pairing of Mismatched Sequences, Nature Struct. Mol. Biol. (2012)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0105. 유전자 발현조절

국가기술지도분류

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녹색기술분류

  • 녹색기술관련 과제 아님
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  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 기초/기반기술
  • 020111. 유전체기반 기술