Enzyme and Protein Engineering Lab


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Enzyme, a kind of specialized protein is biocatalyst to accelerate the reaction in living Biosystems by reducing the required activation energy barrier. Without enzymes, any cellular Biosystems cannot sustain its life system anymore. The acceleration of reaction and specificity of enzymes seems almost miracle since reaction rate can be increased up to billion times higher. Nowadays enzymes can be applied for not only living Biosystems but also chemical industries. Very mild reaction conditions such as room temperature, aqueous phase is enough for the synthesis of many kinds of value-added compounds such as pharmaceuticals, cosmetic ingredients and even bulk chemicals by employing enzymes as biocatalysts. However, even though enzymes seem miracle-like, its stability and reaction charac￾teristics may be not optimized to be utilized for the chemical process. Our lab is actively trying to engineer these enzymes to be more optimized and superior biocatalysts capable of converting raw material to value-added compounds through rational and 3D structure-based design of biocatalysts.

Major research field

C1 gas conversion, Lignin conversion, Cosmetics application

Desired field of research

Enzyme sequence and function relationship, How to increase activity of enzyme?

Research Keywords and Topics

• C1 gas (CO2, CO) enzymatic conversion Production of formate from CO and CO2 using enzymes
• Lignin refinery Lignin de-polymerization enzyme development and production of value added aromatics from lignin
• Application of enzymes for cosmetics Whitening cosmetics using melanin decolorizing enzyme

Research Publications

• BIOMACROMOLECULES/Recombinant lignin peroxidase with superior thermal stability and melanin decolorization efficiency in a typical human skin-mimicking environment/2023-05
• NATURE CATALYSIS/O2-tolerant CO dehydrogenase via tunnel redesign for the removal of CO from industrial flue gas/2022-09
• CHEMICAL ENGINEERING JOURNAL / Two-stage bioconversion of carbon monoxide to biopolymers via formate as an intermediate / 2020-06
• NATURE COMMUNICATIONS / Unassisted solar lignin valorisation using a compartmented photo-electro-biochemical cell / 2019-11
• INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES / Recombinant lignin peroxidase-catalyzed decolorization of melanin using in-situ generated H2O2 for application in whitening cosmetics / Sung, Ho Jun; Khan, Mohd Faheem; Kim, Yong Hwan / 2019-09


• CO hydratase and method for producing formate using the same / Yong Hwan Kim / US Pat. 10,240,170 B2
• CO hydratase and method for producing formate using the same / Yong Hwan Kim / EU Pat. 17,722,365.8


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