Calcium Dynamics Lab

칼슘다이나믹스

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The goal of our research is to understand how calcium signaling is important and diverse. Numerous vital physiological processes such as cell division, proliferation, apoptosis, gene transcription, and immune cell activation are regulated by calcium channels. Consequently, calcium channels are important for many pathological processes and diseases including autism, immune deficiency syndrome, and cardiovascular diseases. We are interested in the dynamic calcium signaling events mediated by voltage-gated calcium channels (VGCCs) and store-operated calcium channels (SOCs).

One more thing!
Recently, we know and have interested in the role of calcium signaling in (coronavirus) viral immunity.

Another goal is to provide effective solutions designed to boost your ability, to ensure you achieve your dreams of success, and to help you be a nice lab citizen.​

Major research field

calcium channel mediated signaling, cellular differentiation, coronavirus, innate immune.

Desired field of research

Research Keywords and Topics

calcium channel signaling
immune system activation
Cell signaling
host cell responses to viral infection (Coronavirus infection)
translational medicine

Research Publications
MORE

1.Proc. Natl Acad Sci U S A Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans. Kim KM, Wijerathne T, Hur JH, Kang UJ, Kim IH, Kweon YC, Lee AR, Jeong SJ, Lee SK, Lee YY, Sim BW, Lee JH, Baig C, Kim SU, Chang KT, Lee KP, Park CY (2018)
2. Science. The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels. Science. (2010)
3. Cell, STIM1 Clusters and Activates CRAC channels via Direct Binding of a Cytosolic Domain to Orai1. Park CY, Hoover PJ., Mullins F, P. Bachhawat, Covington ED., Raunser S., Walz T., Garcia KC., Dolmetsch RE, and Lewis RS, (2009)

Patents

CALCIUM SIGNALING MODULATORS INVOLVING STIM AND ORAI PROTEINS
(61/155,761) (International Publication Number WO 2010/099401A1)
Organic compounds that inhibit or activate store operated calcium channels
(61/459,322) (International Patent Application No. PCT/US2011/064234)

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