Genetic mutations and growth signals in cancer microenvironments can dynamically alter metabolic pathways. This results in increased biosynthesis and abnormal bioenergetics which in turn promote cell proliferation, metastasis and survival and immune destruction avoidance. Furthermore, metabolic remodeling regulates tumor epigenetic alterations by regulating the activity of epigenetic modification enzymes and gene expression in cancer. Therefore, targeting of cancer metabolism may provide new effective therapies to treat cancer. To investigate role of metabolism of cancer we mainly focus on mechanism of metabolic reprograming of cancer especially in hypoxic environmental stress, oncogenic growth signaling and cancer stem cells.