Cancer Biology

암생물학실험실

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암생물학실험실

Cancer Mitochondrial biology
Mitochondria is critical regulatory nodal points intersecting multiple cell death signaling pathways. We are interested in molecular regulatory mechanisms of mitochondrial outer and inner membrane permeabilization (MMP) which is the most important event for 'life or death' decision and is the 'point of no return' in cell death program. Mitochondrial chaperones and related molecules (Hsp90, TRAP1, Hsp60, mtHsp70, and Cyclophilin-D) and Bcl-2 family members regulate the mitochondrial membrane permeabilization and can induce biochemical, physiological, and structural changes in mitochondria. The function of these molecules in MMP and molecular mechansims of their cross-regulation are our primary interest.

Major research field

샤페론에 의한 미토콘드리아 기능조절, 종양면역반응과 종양미세환경, 미토콘드리아 타겟 혁신신약 개발

Desired field of research

대사성 난치질환에서의 미토콘드리아 기능연구, 혁신신약 개발과 사업화 연구

Research Keywords and Topics

1) Cellular functions and molecular regulatory mechanism of the mitochondrial chaperone TRAP1.
2) TRAP1 and client networks: implications for human diseases (Cancer & beyond)
3) Development of TRAP1 inhibitors as anticancer drugs: mitochondria-accumulating and mitochondria-permeable drugs.
4) Cancer stem cells and development of resistance to chemo- and radiation therapies.
5) Tumor microenvironment: metabolic cross-talk between cancer and stromal cells.

Research Publications
MORE

JOURNAL OF MEDICINAL CHEMISTRY / Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. / Hu S, Ferraro M, Thomas AP, Chung JM, Yoon NG, Seol JH, Kim S, Kim HU, An MY, Ok H, Jung HS, Ryu JH, Colombo G, Kang BH. / 2020-03
CANCER RESEARCH / Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells / Park HK, Hong JH, Oh YT, Kim SS, Yin J, Lee AJ, Chae YC, Kim JH, Park SH, Park CK, Park MJ, Park JB, Kang BH / 2019-04
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY / Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1 / Lee C, Park HK, Jeong H, Lim J, Lee AJ, Cheon KY, Kim CS, Thomas AP, Bae B, Kim ND, Kim SH, Suh PG, Ryu JH, Kang BH / 2015-04

Patents

•Kang BH, Kim SY, Yun NG, Lee C, Park DH, "Compound for inhibiting neovascularization factor and use thereof" Dec. 16, 2019, Korea No. 10-2019-0168238.
•Kang, B.H., Park, H.K., et al., "In vivo pan Hsp90 family protein inhibitor Panvotinib-401 as cancer therapeutics" Oct. 26, 2016, Korea No. 10-2016-0140260; Jul. 21, 2017, PCT/KR2017/007907

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