cellular energy metabolism

세포 에너지 대사 실험실

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세포 에너지 대사 실험실

Yoon's laboratory focuses on the molecular regulation of cellular metabolism in metabolic disease using the biochemical approach, cell biology, and signaling and metabolic profiling.

My research topic is 2 parts. First, 1) to develop a metabolic drug for cancer therapy, and 2) to understand the mechanisms of metabolic disease
1) Developing a metabolic drug for cancer therapy
Interestingly, cancer cells have their own favor on metabolites (nutrients). We can characterize the quantitative changes in the metabolites and metabolic pathways using liquid chromatography-mass spectrometry. Using this method, we can find the target metabolites in specific cancer cell types, as well as a new therapeutic strategy focused on the metabolic pathways.

2) Understanding the mechanisms of metabolic disease
Strikingly, despite the importance of lipid metabolism in obesity, which lipid species maintain metabolic homeostasis, and which disrupt essential cellular functions, leading to metabolic disorders remain unknown. I have identified lipids with both beneficial and detrimental roles in skeletal muscle, and my research aims to elucidate their biological and mechanistic function during normal muscle physiology and conditions of dysregulated lipid homeostasis in obesity.

Overall, this research will give a critical and unique insight into how lipid species impact skeletal muscle cell function, and unveil molecular mechanisms through which energy metabolism contributes to metabolic disease. This work will suggest new therapeutic strategies to treat metabolic diseases.

Major research field

Metabolism, biochemistry, muscle biology, metabolic disease, metabolite, lipid metabolism, cancer metabolism

Desired field of research

Cellular energy metabolism, Metabolic signaling in human physiology and metabolic disease

Research Keywords and Topics

Developing a metabolic drug for cancer therapy.
Understanding the mechanisms of metabolic disease.
The research of lipid toxicity and bioactive lipid species.
The study on muscle energy metabolism contributes to muscle biology and disease.

Research Publications

• Cell Metabolism. PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle. Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Wang Y, Agar NR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC. 2020. S1550-4131(20): 30318-1.
• Nature Communications. NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Yoon H, Kim HL, Chun YS, Shin DH, Lee KH, Shin CS, Lee DY, Kim HH, Lee ZH, Ryoo HM, Lee MN, Taeg Oh G, Park JW. 2014. 7;5:5176.
• Cancer Research. FIH is an oxygen sensor in ovarian cancer for G9a/GLP-driven epigenetic regulation of metastasis-related genes. Kang J*, Shin SH*, Yoon H*, Huh J, Shin HW, Chun YS, Park JW. 2017. pii: canres.2506.2017. [* co-first author]
• Molecular Cell. Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity. Yoon H*, Shaw JL*, Haigis MC, Greka A. Mol Cell. 2021. 16;81(18):3708-3730. [* co-first author]




  • LA. 생명과학
  • LA06. 생화학·구조생물학
  • LA0605. 지질생화학


  • 건강한 생명사회 지향
  • 020500. 후보물질 도출 기술


  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님


  • BT 분야
  • 기초/기반기술
  • 020114. 생명현상 및 기능연구