Supramolecular NanoMaterials Lab


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The research theme of the Ryu research group is the development of new disease therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the conventional-drug-free approach for a new anti-cancer/anti-ageing therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer/senescent cells. In addition, the Ryu group have developed a facile synthetic method for highly stable, polymer/protein-modified hollow nanoparticles using a non-covalent approach to enhance in vivo efficacy and target ability to caner and senescent cells.

Major research field

초분자 치료제 (Supramolecular Therapy), 나노의약 (Nanomedicine), 노화 제어

Desired field of research

자기조립을 이용한 질병 치료 분야 (항암, 노화제어 등)

Research Keywords and Topics

Research Keywords :
Supramolecular Therapeutics, Intracellular Self Assembly, Anti-Cancer, Anti-Ageing

Research Interests/Topics :
Nanomedicine for anti-cancer/anti-ageing therapy
Mitochondria Targeting Drug
Intracellular Supramolecular Assembly
Multifunctional Polymers for Lithium Ion Batteries 

Research Publications

S. Kim, B. Jana, E. M. Go, J. E. Lee, S. Jin, E.-K. An, J. Hwang, Y. Sim, S. Son, D. Kim, C. Kim, J.-O Jin*, S. K. Kwak*, J.-H. Ryu* "Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate" ACS Nano 2021, 15, 14492

J. Y. Oh, H. S. Kim, L. Palanikumar, E. M. Go, B. Jana, S. A. Park, H. Y. Kim, K. Kim, J. K. Seo, S. K. Kwak, C. Kim,* S. Kang,* J.-H. Ryu* "Cloaking Nanoparticles with Protein Corona Shield for Targeted Drug Delivery" Nat. Commun. 2018, 9, 4548

Jeena, M. T.; Palanikumar, L.; Go, E. M.; Kim, I.; Kang, M. G.; Lee, S.; Park, S.; Choi, H.; Kim, C.; Jin, S.-M.; Bae, S. C.; Rhee, H.-W; Lee, E.; Kwak, S. K.; Ryu, J.-H.* "Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction”Nat. Commun. 2017, 8, 26  


Conjugate Including Peptide Molecule Capable of Self-Assembly in Cell Organelle and Pharmaceutical Composition for Preventing or Treating Cancer Including Conjugate” US Patent Application Number 15/813,646
Targeted Drug Delivery Platform Using Protein Corona Shield Nanoparticle and a Method for Producing the Same” Korean Patent Application Number 10-2017-0159936


  • NC. 화학
  • NC05. 고분자화학
  • NC0504. 생체 의료용 고분자


  • 건강한 생명사회 지향
  • 020800. 약물전달시스템 기술


  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님


  • NT 분야
  • 나노 바이오 보건
  • 030312. 의약 약물전달 시스템