Supramolecular NanoMaterials Lab


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The research theme of the Ryu research group is the development of new cancer therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the drug-free approach for a new anti-cancer therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer cells. In addition, the Ryu group have developed a facile synthetic method for highly stable,polymer/protein-modified hollow nanoparticles using a non-covalent approach to enhance in vivo efficacy and target ability to caner.
초분자 나노재료 연구실에서는 유기합성을 통해 자극에 반응하는 유기분자, 고분자를 이용한 항암 약물전 달, 암세포 센싱, 초분자 자기조립현상, 합성단백질 구조 및 세포내 기능을 연구 하고 있다. 잘 조립된 나노 구조와 생체-나노물질의 개발을 통하여 세포 역활을 통제하거나 뛰어난 유-무기 하이브리드 물질을 이용하여 나노 생명 기술을 발전시키는것을 목표로 하고 있다



초분자 치료제 (Supramolecular Therapy), 나노의약 (Nanomedicine), 노화 제어


자기조립을 이용한 질병 치료 분야 (항암, 노화제어 등)

Research Keywords and Topics

Research Keywords
Supramolecular Assembly, Synthetic Peptide Assembly, Cancer Drug Delivery초분자 조립, 펩타이드 조립, 암치료를 위한 약물전달체 개발

Research Interests/Topics
Nanomedicine for cancer therapy (암치료를 위한 나노메디신 개발)
Mitochondria Targeting Drug (미토콘드리아 표적지향 약물개발)
Bioactive Supramolecular Assembly (생체반응성 초분자조립 연구)
Multifunctional Polymers for Lithium Ion Batteries (리튬이온전지를 위한 다기능성 폴리머 개발)

Research Publications

J. Y. Oh, H. S. Kim, L. Palanikumar, E. M. Go, B. Jana, S. A. Park, H. Y. Kim, K. Kim, J. K. Seo, S. K. Kwak, C. Kim,* S. Kang,* J.-H. Ryu* "Cloaking Nanoparticles with Protein Corona Shield for Targeted Drug Delivery" Nat. Commun. 2018, 9, 4548 (Aug. 31, 2018)

S. Kim, L. Palanikumar, H. Choi, M. T. Jeena, C. Kim*, J.-H. Ryu* "Intra-Mitochondrial Biomineralization for Inducing Apoptosis of Cancer Cells" Chem. Sci 9, 2474 (2018)

Jeena, M. T.; Palanikumar, L.; Go, E. M.; Kim, I.; Kang, M. G.; Lee, S.; Park, S.; Choi, H.; Kim, C.; Jin, S.-M.; Bae, S. C.; Rhee, H.-W; Lee, E.; Kwak, S. K.; Ryu, J.-H.* "Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction”Nat. Commun 8, 26 (2017)  


Conjugate Including Peptide Molecule Capable of Self-Assembly in Cell Organelle and Pharmaceutical Composition for Preventing or Treating Cancer Including Conjugate” US Patent Application Number 15/813,646
Targeted Drug Delivery Platform Using Protein Corona Shield Nanoparticle and a Method for Producing the Same” Korean Patent Application Number 10-2017-0159936