생체고분자질량분석실

Biomolecular Mass Spectrometery Resource

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Biomolecular Mass Spectrometery Resource

BMSR is a resource of MS technologies for biomolecule analysis in UCRF. Recently Mass spectrometry-based proteomics has become an invaluable tool in modern biological research. BMSR use state of art, high resolution mass spectrometry in combination with liquid chromatography (LC-MS/MS) to analyze complex biological samples in depth. We are focused on protein identification, quantitative proteomics and analysis of PTM(post translational modification) using multiple fragmentation techniques such as CID, ETD, and HCD. We also collaborate with research groups covering a wide variety of topics all with the aim to elucidate mechanisms underlying biological processes in health and disease.

관심분야

Proteomics, Peptidomics, Metabolomics

희망분야

Discovery of novel bioactive peptides, Discovery of novel drug-binding proteins by shotgun purification, Discovery of disease-related biomarkers.

Research Keywords and Topics

연구 키워드
- 단백체학, 펩티드체학, 대사체학

연구 주제
- 생체활성 펩티드 발굴 및 기능 연구
- 약물 작용 단백질 발굴 및 기전 연구
- 질환 관련 바이오마커 발굴 및 활용 연구

Research Publications
MORE

NUCLEIC ACIDS RESEARCH,The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination., Park, J., Lee, S. Y., Jeong, H., Kang, M. G., Haute, L. V., Minczuk, M., Seo, J. K., Jun, Y., Myung, K., Rhee, H. W.*, Lee, C.* (2019)
Journal of the American Chemical Society, Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Chemical Tools in Live Cells., Lee, S. Y., Kang, M. G., Shin, S., Kwak, C., Kwon, T., Seo, J. K. *, Kim, J. S. *, Rhee, H. W. * (2017)
ACS Central Science, Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells., Lee, S. Y., Lee, H., Lee, H. K., Lee, S. W., Ha, S. C., Kwon, T., Seo, J. K.*, Lee, C.*, and Rhee, H. W.* (2016)

Patents

[국내] Peptide inhibiting infection of human immunodeficiency virus type 1 and the use thereof., Lee, M.K., Seo, J.K., Kim, K.L., Kim, H.K., Cho, J.H. (2004)
[국내] Intracellular calcium ion increasing peptide in human T cells., Bae, Y.S., Seo, J.K., Ryu, S.H., and Suh, P.G. (2001)

국가과학기술표준분류

  • LA. 생명과학
  • LA06. 생화학·구조생물학
  • LA0603. 단백질체학

국가기술지도분류

  • 건강한 생명사회 지향
  • 021800. 생체정보생성/저장 기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 기초/기반기술
  • 020112. 단백질체 연구