Micro Tissue Engineering & Nanomedicine

미세조직공학 및 나노의학

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미세조직공학 및 나노의학

Human body is the most complex organic system in nature. To understand its integrated physiological functions, it is important to recapitulate multi-cellular interactions in tissue and map networks of dynamical organ system in vitro. An ‘Organ on a chip’ is microfluidic cell culture device that contains microenvironment of living organ, which could revolutionize drug development as alternatives to animal testing. We are developing ‘organ-on-a-chip’ using multiple cell types or organoid system to emulate human organs in different physiological states. For precision medicine, we are also creating personalized organ model using stem cell source. Through human in vivo-like organ model, we develop new approach to screen drug and targeted drug delivery, and test drug and observe reactions in real time. Finally, we aim to develop safe and efficient nanomedicines which target specific physiological microenvironment.


Organ-on-a-Chip, Organoid, Microfluidics, Nanotherapeutic, Phage Display


Personalized Medicine, Stem Cell Engineering

Research Keywords and Topics

- Organ-on-a-Chip, Organoid, BioChip, Nanotherapeutic, Phage Display
- 오간온어칩, 오가노이드, 바이오칩, 나노의약, 파지디스플레이

Research Publications

Nature Biomedical Engineering, Robotic fluidic coupling and interrogation of multiple vascularized organ chips, 4, 407-420 (2020)
Nature Communications, Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies, 13, 10(1):2621 (2019)
Biomaterials, Enhanced BBB permeability of osmotically active poly(mannitol-co-PEI) modified with rabies virus glycoprotein via selective stimulation of caveolar endocytosis for RNAi therapeutics in Alzheimer’s disease, 38(3), 61-71 (2015)


  • LA. 생명과학
  • LA07. 융합바이오
  • LA0701. 바이오칩


  • 건강한 생명사회 지향
  • 021300. 바이오 칩/센서기술


  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님


  • BT 분야
  • 보건의료 관련응용
  • 020213. 생체조직 재생기술