The human body stands as nature's most intricate organic system. To gain a comprehensive understanding of its integrated physiological functions, it becomes crucial to recreate multi-cellular interactions within tissues and map out the networks of dynamic organ systems in vitro. An innovative solution in this pursuit is the development of 'Organ on a chip,' a microfluidic cell culture device that replicates the microenvironment of living organs. This advancement holds the potential to revolutionize drug development by providing alternatives to animal testing. Our current focus lies in constructing 'organ-on-a-chip' systems that incorporate multiple cell types or organoids, capable of emulating human organs in various physiological states. Additionally, for the advancement of precision medicine, we are actively involved in creating personalized organ models utilizing stem cells as a source. By employing these human in vivo-like organ models, we aim to develop novel approaches for drug screening, targeted drug delivery, and real-time observation of drug reactions. Ultimately, our objective is to develop safe and efficient nanomedicines that specifically target distinct physiological microenvironments, thus paving the way for groundbreaking advancements in the field.