Molecular Metabolism Laboratory

분자대사학연구실

관련기사 바로가기
분자대사학연구실

Our research group is mainly focusing on the adipocyte biology at the level of metabolism and cancer. Through underlying the molecular mechanisms of obesity-related metabolic diseases, we aim to develop novel therapeutics for the metabolism and cancers. Main research topics are listed in below;
· Adipose tissue remodeling via modulation of extracellular matrix proteins
· Development of adipokine-based therapeutics for obesity-related metabolic diseases
· Underlying the signaling networks between stromal adipocytes and cancer cells within the tumor microenvironment
· Underlying the molecular mechanisms of metabolic stress-induced alteration of cancer cell behaviors

Major research field

Adipocyte, Obesity, Diabetes, Cancers, Therapeutics

Desired field of research

ECM and fibrotic diseases

Research Keywords and Topics

· Obesity-related metabolic diseases and cancers
· Adipose tissue remodeling
· Extracellular matrix protein (ECM) and fibrosis

Research Publications
MORE

· Oh J, Park C, Kim S, Kim M, Kim C-S, Jo W, Park S, Yi G-S, and Park J*. High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity. Metabolism-Clinical and Experimental (145) 155629 (IF: 13. 934) 2023.08
· Lee C, Kim M, Park C, Jo W, Seo JK, Kim S, Oh J, Kim C-S, Ryu HS, Lee K-H and Park J*. Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia. Nature Communications 14(1) 439 (IF: 17. 694) 2023.02
· Jo W, Kim M, Oh J, Kim C-S, Park C, Yoon S, Lee C, Kim S, Nam D, Park J*. MicroRNA-29 ameliorates fibro-inflammation and insulin resistance in HIF1α-deficient obese adipose tissue by inhibiting endotrophin generation. Diabetes (IF: 9.461) 2022.08. 71(8)1746-1762

Patents

· [국내] 엔도트로핀 절단 효소의 저해제를 포함하는 엔도트로핀 활성 저해용 조성물 및 이의 용도. 박지영, 김민, 이상민, 조우빈. 2020.02.03 (대한민국)
· [국외] Endotrophin neutralization and use thereof. Philipp.E. Scherer, Jiyoung Park, Zhiqiang An. 2017.03.28 (USA Patent)

국가과학기술표준분류

  • LA. 생명과학
  • LA01. 분자세포생물학
  • LA0103. 세포분화/사멸

국가기술지도분류

  • 건강한 생명사회 지향
  • 021100. 생체신호처리기술

녹색기술분류

  • 녹색기술관련 과제 아님
  • 녹색기술관련 과제 아님
  • 999. 녹색기술 관련과제 아님

6T분류

  • BT 분야
  • 보건의료 관련응용
  • 020212. 난치성 질환 치료기술